Glioblastoma multiforme (GBM) is the most aggressive primary brain tumor, known for its invasiveness, therapy resistance, and the challenge posed by the blood-brain barrier (BBB). This study presents a novel, dual-functionalized nanovesicular system for intranasal delivery of thymoquinone (TH), encapsulated in PEGylated chitosan-coated NVs and conjugated with lactoferrin (Lf). This formulation (TH-Lf-PEG-CS-NVs) was optimized using […]
The post Engineering of Dual-Functionalized Intranasal Nanovesicles Embedded with Thymoquinone for Targeted Modulation of the PI3K/AKT Pathway in Glioblastoma Therapy. first appeared on Physician’s Weekly.
